Evidence map›Paper›PMID 42527491›Full record

Articlenpj health systems2025

Human evaluation of large language models in healthcare: gaps, challenges, and the need for standardization.

Raghav Awasthi, Atharva Bhattad, Sai Prasad Ramachandran, Shreya Mishra, Ashish K Khanna, Jacek B Cywinski, Kamal Maheshwari, Dwarikanath Mahapatra, Izabella DiRosa, Anabelle Cohen and 9 more

Abstract read
In one paragraph

Article in npj health systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Validating LLM judges for automated oversight of patient communication.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. "MELMA" in otolaryngology: Medical evaluation of large language model answers. Clinician-rated scoring (MELMA-Q) and web-based auditing (MELMA-W) novel tools for AI assessment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Raghav AwasthiBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Atharva BhattadBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Sai Prasad RamachandranBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Shreya MishraBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Ashish K KhannaBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Jacek B CywinskiBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Kamal MaheshwariBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Dwarikanath MahapatraBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Izabella DiRosaBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Anabelle CohenBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Hajra ArshadBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Aarit AtrejaBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Asma AlshukailiBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Aryan VohraBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Nishant SinghBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Francis A PapayBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Ashish AtrejaBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Rahul KashyapBrainXAI Research, BrainX LLC, Cleveland, OH, USA.
Piyush MathurBrainXAI Research, BrainX LLC, Cleveland, OH, USA. pmathurmd@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Publications related to experimentation with Large Language Models (LLMs) in healthcare are rapidly increasing. While human evaluation remains the gold standard for evaluating LLMs, there is still a lack of standardization in its implementation. In this review article, we systematically examine studies involving LLMs in healthcare that have conducted human evaluations. We analyze the metrics used, assess their variability across studies. We also propose a standardized framework along with an interactive open web application HumanELY, to facilitate human evaluation. We believe that use of HumanELY will provide an opportunity for consistent, comprehensive, reliable, reproducible, and measurable human evaluations of LLM in healthcare. HumanELY is publicly available at https://www.brainxai.com/humanely .

Identifiers

PMID42527491
PMCPMC13354174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.