Evidence map›Paper›PMID 42527473›Full record

Articlenpj biomedical innovations2026

Controlled release of CD200 inhibits inflammatory macrophages and chondrocyte catabolism.

Shreedevi Kumar, Folly M Patterson, Tiffany Conklin, Ssu-Chieh J Hsu, Vijaykumar Meli, Kiara Chan, Kyle D Allen, Wendy F Liu, Blanka Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shreedevi Kumar *J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Folly M Patterson *J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Tiffany ConklinJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Ssu-Chieh J HsuDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Vijaykumar MeliDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Kiara ChanJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Kyle D AllenJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Wendy F LiuDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Blanka SharmaJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. blanka.sharma@bme.ufl.edu.

Funding

Innervation of the knee and TMJUC2AR082196 · NIAMS · UNIVERSITY OF FLORIDA · PI Kyle D Allen, Alejandro Jose Almarza · 2022 to 2026
$11.2M
the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Biophysical regulation of macrophage functionR01AI151301 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2020 to 2024
$2.9M
Nanoparticle targeting within the joint for site-specific delivery of osteoarthritis therapeuticsR01AR071335 · NIAMS · UNIVERSITY OF FLORIDA · PI SHARMA, BLANKA · 2018 to 2022
$1.8M
National Institute of Allergy and Infectious Diseases R01AI151301-01NIAID NIH HHS R01 AI151301NIAMS NIH HHS R01 AR071335NIAMS NIH HHS R01AR071335NIAMS NIH HHS UC2 AR082196NIAMS NIH HHS UC2AR082196-S2NIA NIH HHS T32 AG049673NIA NIH HHS T32AG049673U.S. Department of Defense W81XWH-18-1-0147
6 · The paper itself

Abstract

In the osteoarthritic joint, activated macrophages release pro-inflammatory factors that promote cartilage degeneration. The CD200:CD200R immune checkpoint pathway is a promising therapeutic target that inhibits classical macrophage activation. We hypothesized that the presentation of CD200 to macrophages would shift their cytokine profile from pro-inflammatory to pro-regenerative, thereby reducing chondrocyte catabolism. CD200 encapsulated in poly(lactide-co-glycolide) microparticles (MPs) were incubated with murine bone marrow-derived macrophages. CD200 MP treatment reduced protein and gene expression of pro-inflammatory mediators in M1 macrophages and increased protein and gene expression of anti-inflammatory mediators in M2 and M1/2 macrophages. Conditioned media from CD200 MP-treated M1 macrophages reduced the expression of catabolic enzyme genes in chondrocytes. This study is the first to demonstrate that delivery of CD200 alters the inflammatory cascade and paracrine signaling to chondrocytes. There is significant potential for the CD200:CD200R inhibitory signaling pathway to be leveraged as an intra-articular treatment of OA.

Identifiers

PMID42527473
PMCPMC13421671

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.