ArticleBirth defects research2026
Intentional Dexketoprofen Overdose During Pregnancy: Maternal and Fetal Outcomes in Three Cases.
Article in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDexketoprofen trometamol is a widely used short-acting nonsteroidal anti-inflammatory drug. Despite its widespread clinical use, pregnancy-specific safety data for dexketoprofen as an individual agent are lacking, and no previous report has described maternal or fetal outcomes following overdose in pregnant women. CASES: We present three cases of intentional dexketoprofen overdose during pregnancy. Case 1 involved a 33-year-old woman at 8 weeks of gestation who ingested dexketoprofen with ibuprofen, pseudoephedrine, and cefuroxime; she delivered a healthy male infant at 37 weeks with no congenital anomalies on follow-up. Case 2 involved a 36-year-old woman at 17 weeks who ingested dexketoprofen with ergotamine tartrate, mecloxamine, caffeine, and paracetamol; she experienced a spontaneous abortion at 20 weeks, complicated by cyst rupture requiring hysterectomy. Case 3 involved a 29-year-old woman at 6 weeks who ingested dexketoprofen, paracetamol, and chlorpheniramine, and underwent elective termination at 10 weeks.
conclusionsThe three cases demonstrated heterogeneous pregnancy outcomes. No congenital anomalies were identified in the single evaluable live-born infant. Multiple co-ingested agents substantially complicate causal attribution, most notably ergotamine tartrate in Case 2. The limited case number and outcome heterogeneity preclude identification of a consistent pattern of fetal adverse effects or definitive conclusions regarding fetal risk. All overdoses were intentional, underscoring the importance of integrating psychiatric assessment into toxicological management during pregnancy. These cases represent the first available observational data on maternal and fetal outcomes following intentional dexketoprofen overdose in pregnancy, highlighting the need for a multidisciplinary approach in this clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.