Evidence map›Paper›PMID 42526916›Full record

ArticleBMJ open2026

Randomised superiority trial evaluating an online transdiagnostic emotion regulation treatment for adolescents with mental health conditions: study protocol.

Katja Sjöblom, Martin Bellander, Jannike Nilbrink, Maria Zetterqvist, Filipa Sampaio, Erik Hedman-Lagerlöf, Clara Hellner, James J Gross, Hugo Hesser, Johan Bjureberg

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06067165 (Primary Care Online Emotion-regulation Treatment), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06067165 narecruitingnot on this map

Primary Care Online Emotion-regulation Treatment (POET)

TypeinterventionalSponsorKarolinska InstitutetRan2023 to 2031Enrolled388ConditionsMental Health IssueArmsPOET feeling, Supportive treatment
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katja SjöblomCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden katja.sjoblom@ki.se.ORCID 0009-0009-4925-3133
Martin BellanderCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-0377-4979
Jannike NilbrinkCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Maria ZetterqvistClinical Department of Child and Adolescent Psychiatry in Linköping and Center for Social and Affective Neuroscience, Linkoping University Department of Biomedical and Clinical Sciences, Linköping, Sweden.ORCID 0000-0003-2465-8029
Filipa SampaioDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-5540-9853
Erik Hedman-LagerlöfDivision of Psychology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Clara HellnerCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
James J GrossDepartment of Psychology, Stanford University, Stanford, California, USA.ORCID 0000-0003-3624-3090
Hugo HesserSchool of Behavioural, Social and Legal Sciences, Örebro University, Örebro, Sweden.ORCID 0000-0002-9736-8228
Johan BjurebergCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMental health conditions are prevalent during adolescence, but access to early evidence-based treatments remains limited. Scalable, online, theory-based transdiagnostic interventions delivered in primary care have the potential to reduce this treatment gap, but the effectiveness remains unknown. The objective is to investigate whether an online transdiagnostic emotion regulation treatment for adolescents with mental health conditions is superior to an active control treatment. METHODS AND ANALYSIS: This single-blind, randomised clinical superiority trial will evaluate the effectiveness and cost-effectiveness of an online transdiagnostic emotion regulation treatment for adolescents with mental health conditions within primary care in Sweden. We aim to include 388 participants (adolescents aged 12-17 years with mental health conditions and their parents), recruited through primary care and self-referral. Patients will be randomised to either an online transdiagnostic emotion regulation treatment or an active control treatment. Participants will receive 6 weeks of therapist-guided online transdiagnostic emotion regulation treatment or an active control treatment consisting of 6 weeks of online supportive treatment. Parents will participate in parallel with their adolescents in both conditions and will receive an online parent course. The primary outcome, assessed by blinded assessors, will be clinical global symptom severity measured with the Clinical Global Impressions-Severity scale. Treatment effectiveness will be evaluated through blinded assessment and self-assessment at primary endpoint (immediately after treatment) and 3 months after treatment. In addition, a health economic evaluation will be conducted. The study will be undertaken between October 2023 and July 2026. ETHICS AND DISSEMINATION: The study has obtained ethical approval from the Swedish Ethical Review Authority. Findings will be disseminated in peer-reviewed publications and presented at scientific conferences. TRIAL REGISTRATION NUMBER: NCT06067165.

Indexed as

Emotional RegulationMental DisordersAdolescentChildCost-Effectiveness AnalysisEquivalence Trials as TopicFemaleHumansMalePrimary Health CareRandomized Controlled Trials as TopicSingle-Blind MethodSwedenAdolescentClinical TrialHEALTH ECONOMICSMENTAL HEALTHPrimary CareTreatment Outcome

Identifiers

PMID42526916
PMCPMC13422934

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.