ArticleAnimal bioscience2026
Genome-wide identification of long non-coding RNAs in pigs and their roles in muscle development.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveLong non-coding RNAs (lncRNAs) regulates complex traits in pigs and the systematic annotation and functional roles of these genes remain poorly understood. This study aimed to construct a comprehensive porcine lncRNA atlas and explore the regulatory role of lncRNAs in muscle development.
methodsWe used 8,871 strand-specific RNA-seq datasets to identify porcine lncRNAs. Their transcriptional characteristics, tissue specificity, evolutionary conservation, and expression quantitative trait locus (eQTL)-supported regulatory relationships were esamined. Single-cell RNA-seq, Hi-C, H3K27ac ChIP-seq, and population differentiation analyses were further incorporated to investigate candidate lncRNAs involved in muscle development.
resultsWe identified 50,203 porcine lncRNA genes with greater tissue specificity and lower expression levels than protein-coding genes. A subset of lncRNAs showed sequence conservation across mammals. Integration with pigGTEx data identified extensive eQTLsupported lncRNA-mRNA candidate regulatory pairs enriched in active promoter and enhancer chromatin states. Single-cell and multi-omics analyses highlighted PRANCR as a candidate regulator of postnatal muscle growth in Laiwu pigs. A highly distinct enhancer variation (chr5:g.34155013T>C; Sscrofa11.1) could affect SOX8 binding and regulate PRANCR expression in satellite stem cells.
conclusionThe current study provides the most comprehensive porcine lncRNA resource currently available and proposes a potential enhancer-lncRNA regulatory mechanism that contributes to muscle development in pigs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.