ArticlePoultry science2026
Multi-omics analysis of the gut-liver axis reveals the health hazards of embryonic egg exposure to zearalenone in chicks.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zearalenone (ZEN), a widespread Fusarium-derived mycotoxin, poses health risks to animals and humans through contaminated food chains. However, its transgenerational effects following embryonic egg exposure on avian development and chick health remain poorly characterized.This study employed embryonic egg injection and multi-omics approaches to evaluate the impacts of ZEN (0, 5, 50, or 500 μg/egg) administered to Hy-line Brown eggs on day 5 of incubation. ZEN exposure significantly decreased hatchability and initial chick weight. During the 20-day post-hatch period, it induced dose-dependent reductions in net weight, average daily gain, and average daily feed intake, while increasing the feed conversion ratio.Histopathology showed intestinal inflammation and structural damage, coupled with gut microbiota dysbiosis, notably an elevated abundance of pathogenic bacteria such as Escherichia coli. ZEN also caused liver injury, manifested by elevated serum biochemical indices, oxidative stress, and inflammatory responses. Hepatic metabolomics revealed pronounced alterations in metabolites and pathways associated with lipid metabolism, autophagy, and antioxidant defense.Correlation analyses indicated interconnections between gut microbiota dysbiosis and hepatic metabolic disturbances, suggesting mediation of ZEN developmental toxicity via the gut-liver axis. These results elucidate novel mechanisms of ZEN embryotoxicity and underscore the need to control ZEN contamination in poultry production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.