ArticleAmerican journal of physiology. Cell physiology2026
Dysregulated iron metabolism in remodeling of aging asthmatic human airways.
Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Iron is essential for cellular function, and lung cells are no exception. Previous studies have demonstrated an association between increased level of iron in the lung and aging and age-related lung diseases, including pulmonary fibrosis and asthma in the elderly (AIE). However, the mechanisms underlying the accumulation of iron with aging or AIE, or the cell types involved, remain understudied. In the context of asthma, airway smooth muscle is a key cell type contributing to contractility as well as airway remodeling (proliferation, fibrosis). In this study, we characterized iron levels and regulation in human airway smooth muscle cells (hASMs) from young (<45 yr), old (≥65 yr), and AIE (≥65 yr) male/female patients, and investigated the contribution of iron overload in hASM to airway remodeling. Cells were treated with ferric ammonium citrate (FAC; 100 μM; 72 h) or iron chelator deferoxamine (DFO; 100 µM; 72 h). Basal levels of intracellular ferrous iron (Fe
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