ArticleJournal of veterinary internal medicine2026
Survival outcomes of dogs with multicentric lymphoma treated with sequential half-body radiotherapy and L-CHOP without maintenance chemotherapy.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundL-CHOP (L-asparaginase, cyclophosphamide, doxorubicin, vincristine, prednisone) is the standard therapy for lymphoma in dogs, but relapse and limited long-term survival are common. Given the radiosensitivity of lymphoma, sequential half-body radiotherapy (HBRT) has been investigated to improve outcomes. HYPOTHESIS/
objectivesEvaluate progression-free survival (PFS), overall survival (OS), and adverse events in dogs treated with a no-maintenance L-CHOP protocol combined with low-dose-rate (LDR, 6 Gy; 8-14 cGy/min) HBRT compared to L-CHOP alone. ANIMALS: Client-owned dogs with intermediate- to high-grade multicentric lymphoma treated with L-CHOP-LDR-HBRT or a 6-month L-CHOP protocol (controls).
methodsMedical records were retrospectively reviewed in this case-control study. Adverse events were graded using VCOG-CTCAE v2 (Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events guidelines) criteria.
resultsSeventy-five dogs received L-CHOP-LDR-HBRT and were compared with 115 controls. Median PFS and OS for the L-CHOP-LDR-HBRT group were 532 days (95% confidence interval [CI], 389-782) and 752 days (95% CI, 526-963), significantly longer than in controls (296 days [95% CI, 260-331] and 457 days [95% CI, 382-553], respectively, P < .0001). A delay in irradiating the caudal half negatively affected PFS and OS. Adverse event data were available for 30 dogs treated with L-CHOP-LDR-HBRT; most were low-grade, with grade 3 and 4 toxicities occurring in 4.5% of all administered treatments. One dog required hospitalization after HBRT. Dose reductions and treatment delays were observed in 39 and 74 instances, respectively, over the 28-week protocol in this cohort. CONCLUSIONS AND CLINICAL IMPORTANCE: Combining L-CHOP with LDR-HBRT, without maintenance chemotherapy, might substantially extend PFS and OS over L-CHOP alone in dogs with multicentric lymphoma, with predominantly mild, manageable toxicities.
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