Observational studyAnnals of medicine2026
Protocol for a cohort study: evaluating the effect of neoadjuvant immunochemotherapy on intraoperative remifentanil consumption during IoC2-guided anesthesia in elderly patients with esophageal cancer.
Observational study in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe influence of neoadjuvant immunochemotherapy (nICT) on intraoperative opioid consumption during esophagectomy for cancer is not well understood. IoC2 enables real-time antinociceptive depth monitoring. This study assesses nICT's effect on remifentanil requirements in elderly patients using IoC2.
methodsThis prospective observational cohort study will be conducted at Jiangsu Cancer Hospital. Sixty patients scheduled for esophagectomy will be enrolled. Patients will be divided into the nICT group ( DISCUSSION: This study aims to clarify the effect of neoadjuvant therapy on opioid requirements during esophageal cancer surgery. By employing precise IoC2 monitoring, we aim to establish a methodological basis for developing individualized, precise anesthesia-analgesia strategies and to provide prospective evidence for their clinical application.
trial registrationThe study protocol is registered with the Chinese Clinical Trial Registry under registration number ChiCTR2500105958, dated July 15, 2025.
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