Evidence map›Paper›PMID 42525750›Full record

ArticleScience advances2026

Direct single-molecule visualization of Hsp90-mediated relief of an Hsp70-folding block.

Nicholas R Marzano, Bailey Skewes, Shannon McMahon, Lauren Rice, Dezerae Cox, Antoine M van Oijen, Heath Ecroyd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas R MarzanoMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0000-0002-8436-8683
Bailey SkewesMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.
Shannon McMahonMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0009-0009-3227-718X
Lauren RiceMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.
Dezerae CoxMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0000-0002-5345-8360
Antoine M van OijenFaculty of Medicine and Health, University of Sydney, G02 Jane Foss Russell Building, Sydney, NSW 2006, Australia.ORCID 0000-0002-1794-5161
Heath EcroydMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0000-0001-7574-0044

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock protein 70 (Hsp70) and Hsp90 are essential molecular chaperones that cooperate to fold diverse client proteins, yet how their activities are coordinated to remodel clients remains unclear. To address this, we used a combination of single-molecule fluorescence resonance energy transfer and total internal reflection fluorescence microscopy to observe individual firefly luciferase proteins during sequential engagement with

Indexed as

Escherichia coli ProteinsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsProtein FoldingSingle Molecule ImagingAdenosine TriphosphateBinding SitesEscherichia coliFluorescence Resonance Energy TransferKineticsProtein BindingProtein ConformationAdenosine TriphosphatednaK protein, E coliEscherichia coli ProteinsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHtpG protein, E coli

Identifiers

PMID42525750
PMCPMC13418734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.