Evidence map›Paper›PMID 42525743›Full record

ArticleScience advances2026

Determining the molecular and physiological actions of subtype-selective nanobodies of GABA

Jose Enrique Gonzalez-Prada, Sulin Liu, Chuhan Shang, Chloe S Chernoff, Damian P Bright, Martin Mortensen, Charlotte F Jones, Stephanie Nestorow, Vikram Babu Kasaragod, Wan-Na Chen and 18 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jose Enrique Gonzalez-PradaDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0009-0004-2998-1989
Sulin LiuDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6776-2216
Chuhan ShangDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Chloe S ChernoffDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2131-0740
Damian P BrightDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0001-9130-2677
Martin MortensenDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0002-5873-7107
Charlotte F JonesDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Stephanie NestorowDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0009-0007-2712-6817
Vikram Babu KasaragodDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1241-4038
Wan-Na ChenDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Saad HannanDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0003-4594-0808
Jianchong ZhouDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0009-0000-1211-6885
Alexander W E DunnDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1504-499X
Asma SoltaniDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Richard J TurnerDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0009-0006-8330-4828
Natasha M DugganDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Yin YuanDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0009-0001-5659-6566
Ayla A WahidDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8128-9632
Steven W HardwickCryoEM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9246-1864
Suzanne ScottMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-5830-8943
Dimitri Y ChirgadzeCryoEM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9942-0993
Els PardonStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID 0000-0002-2466-0172
Jan SteyaertStructural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID 0000-0002-3825-874X
A Radu AricescuMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
Ole PaulsenDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-2258-5455
David BelinDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7383-372X
Trevor G SmartDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0002-9089-5375
Paul S MillerDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6512-9441

Funding

Wellcome Trust
6 · The paper itself

Abstract

γ-Aminobutyric acid type-A (GABA

Indexed as

Receptors, GABA-ASingle-Domain AntibodiesAllosteric RegulationAnimalsCryoelectron MicroscopyHumansModels, MolecularProtein BindingReceptors, GABA-ASingle-Domain Antibodies

Identifiers

PMID42525743
PMCPMC13418544

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.