ArticleScience advances2026
Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS.
Minghe Shen, Zhidan Li, Guojiao Huang, Yue Zhang, Siyue Wen, Fengru Guo, Yingkun Guo, Liguo Zhang, Xuelian He
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Minghe ShenCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.ORCID 0009-0005-8316-6560 Zhidan LiCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.ORCID 0000-0002-7541-0157 Guojiao HuangCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yue ZhangCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Siyue WenCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Fengru GuoCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Yingkun GuoCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.ORCID 0000-0001-8437-9887 Liguo ZhangDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Xuelian HeCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Disease of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.ORCID 0009-0005-6448-2445 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Proper function of the central nervous system (CNS) requires adequate blood supply to both gray and white matter, yet the mechanisms governing the region-specific angiogenesis remain poorly understood. Through analyzing glial cell profiles combined with genetic ablation approaches, we uncover distinct pro-angiogenic programs in astrocytic and oligodendroglial lineages that differentially regulate gray and white matter vascularization. Astrocyte depletion selectively disrupted gray matter angiogenesis, whereas oligodendrocyte lineage loss caused white matter hypovascularization. Gray matter astrocytes are selectively enriched for the hypoxia-inducible factor HIF1α and promote vascular growth via VEGF-dependent signaling, while the oligodendrocyte-enriched chromatin-remodeler CHD8 directly activated pro-angiogenic genes, including
Indexed as
AngiogenesisCentral Nervous SystemNeovascularization, PhysiologicNeurogliaAnimalsAstrocytesCell LineageGray MatterHypoxia-Inducible Factor 1, alpha SubunitMiceOligodendrogliaSignal TransductionWhite MatterHypoxia-Inducible Factor 1, alpha Subunit
Identifiers
PMID42525738
PMCPMC13418536
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