Evidence map›Paper›PMID 42525541›Full record

ArticleMolecular biology of the cell2026

A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.

Sarah E Clark, Siobhan C Morris, Joseph B Dordor, Lawrencia S Amo, Renick Wiltshire, Taino Encarnacion, Maik C Bischoff, Mark Peifer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sarah E ClarkDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.ORCID 0009-0001-4478-8202
Siobhan C MorrisDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.
Joseph B DordorDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.
Lawrencia S AmoDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.
Renick WiltshireDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.
Taino EncarnacionDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.
Maik C BischoffInstitute of Integrative Cell Biology and Physiology, Universität Münster, Münster 48149 Deutschland.ORCID 0000-0002-6995-8159
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280.ORCID 0000-0003-1412-3987

Funding

Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
NIGMS NIH HHS R35 GM118096
6 · The paper itself

Abstract

Animal tissues have diverse architectures and cell behaviors across the epithelial-mesenchymal spectrum. Cell adhesion mediated by classical cadherins is foundational. Cadherins nucleate complexes of dozens of proteins connecting junctions to the cytoskeleton and signaling downstream. Many junctional proteins are well-studied in epithelia, but less is known about roles during mesenchymal migration. The nascent myotubes of the pupal

Indexed as

Adherens JunctionsDrosophila ProteinsTestisAnimalsCadherinsCell AdhesionCell MovementDrosophila melanogasterEpithelial CellsGlycogen Synthase Kinase 3Intracellular Signaling Peptides and ProteinsMaleMorphogenesisbaz protein, DrosophilaCadherinsDrosophila ProteinsGlycogen Synthase Kinase 3Intracellular Signaling Peptides and ProteinsPar-1 protein, Drosophila

Identifiers

PMID42525541
PMCPMC13492156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.