ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026
High Glucose Supplementation Aggravates Experimental Autoimmune Epididymo-orchitis via Localized Th17 Skewing in the Male Reproductive Tract.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic epididymo-orchitis contributes significantly to male infertility through immune cell infiltration and pro-inflammatory cytokine elevation. High glucose intake promotes Th17 differentiation and autoimmunity, but its effects on autoimmune testicular inflammation remain unclear.
objectivesTo determine whether chronic high glucose supplementation exacerbates experimental autoimmune epididymo-orchitis (EAEO), impairs spermatogenesis, and drives CD4 MATERIALS AND
methodsEAEO was induced in male C57BL/6 mice with or without chronic 10% glucose supplementation in drinking water. Sperm parameters, ROS levels, apoptosis, and histopathology were evaluated. CD4
resultsHigh glucose intake accelerated EAEO progression, markedly worsening sperm concentration and motility, elevating sperm ROS, increasing germ cell apoptosis, and causing severe histopathological damage. In the reproductive tract, glucose induced an upward trend of CD4 DISCUSSION AND
conclusionChronic high glucose exacerbates EAEO by intensifying oxidative stress, apoptosis, and tissue injury while promoting a late-phase, tissue-restricted Th17-biased CD4
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