Evidence map›Paper›PMID 42525513›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A posttranslational modification of fimbriae drives pathogenicity in

Genevieve S Dobihal, Kristen Lewis, Tian Huai Shen, Carmen M Herrera, Lisa Yu, Jonathan Barasch, M Stephen Trent, Josué Flores-Kim, Anne-Catrin Uhlemann

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Genevieve S DobihalDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032.
Kristen LewisDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032.
Tian Huai ShenDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY 10032.
Carmen M HerreraDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0002-8343-4837
Lisa YuDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032.ORCID 0009-0009-9101-6684
Jonathan BaraschDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY 10032.ORCID 0000-0002-6723-9548
M Stephen TrentDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0001-6134-1800
Josué Flores-KimBiochemistry and Molecular Biotechnology Department, UMass Chan Medical School, Worcester, MA 01605.
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032.ORCID 0000-0002-9798-4768

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7M
Synthesis and transport of outer membrane components across the Gram-negative cell envelopeR01AI176776 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.5M
The role of cardiolipin in the biogenesis of the Gram-negative bacterial cell envelopeR01AI174416 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.4M
Columbia Integrated Training Program in Infectious Diseases ResearchT32AI100852 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK, Anne-Catrin Uhlemann · 2013 to 2026
$2.2M
Discovery and characterization of bacterial cell envelope assembly and remodeling networks that modulate tolerance to antibioticsR35GM150669 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Josue Flores-Kim · 2023 to 2026
$1.7M
Mentoring program in patient-oriented research in microbial genomicsK24AI183182 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anne-Catrin Uhlemann · 2024 to 2026
$606k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) K24AI183182HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI174416HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI176776HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI100852HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54DK104309HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM150669NCI NIH HHS P30 CA013696NIAID NIH HHS K24 AI183182NIAID NIH HHS R01 AI174416NIAID NIH HHS R01 AI176776NIAID NIH HHS T32 AI100852NIDDK NIH HHS U54 DK104309NIGMS NIH HHS R35 GM150669
6 · The paper itself

Abstract

Antimicrobial resistance is a severe public health burden. Especially concerning are multidrug resistant (MDR) infections, which restrict treatment options and significantly increase mortality risk. A major cause of MDR infections worldwide is carbapenem-resistant

Indexed as

Fimbriae, BacterialKlebsiella pneumoniaeProtein Processing, Post-TranslationalBacterial ProteinsCarbapenemsDrug Resistance, Multiple, BacterialGene Expression Regulation, BacterialKlebsiella InfectionsVirulenceBacterial ProteinsCarbapenemsantimicrobial resistancefimbriaeKlebsiella pneumoniaepathogenesissignaling system

Identifiers

PMID42525513
PMCPMC13419641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.