Evidence map›Paper›PMID 42525372›Full record

ArticleMolecular and cellular biochemistry2026

Quercetin exerts radioprotective effects against radiation-induced intestinal injury with involvement of the PI3K-AKT/Caspase-3 axis.

Qing Guo, Zhibing Tang, Zhenyu Hou, Ge Yan, Jiaxuan Wang, Man Zhang, Ruige Ma, Juan Wang, Qiong Feng, Zhen Wang and 2 more

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qing Guo *International Joint Laboratory of Catalytic Chemistry, College of Sciences, Innovation Institute of Carbon Neutrality, Shanghai University, Shanghai, China.
Zhibing Tang *Department of Orthopaedic Surgery, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.
Zhenyu HouDepartment of Radiation Oncology, Nanyang Central Hospital, Nanyang, China.
Ge YanState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Jiaxuan WangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Man ZhangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Ruige MaState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Juan WangNursing Department of Rugao Hospital of Traditional Chinese Medicine, Nantong, 226500, China.
Qiong FengState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Zhen WangDepartment of Orthopaedic Surgery, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China. qiushui21@163.com.
Chunlei WangInternational Joint Laboratory of Catalytic Chemistry, College of Sciences, Innovation Institute of Carbon Neutrality, Shanghai University, Shanghai, China. wangchunlei1982@shu.edu.cn.
Lin ZhaoState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China. zhaolin@suda.edu.cn.

Funding

he Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University YXY2304035he National Natural Science Foundation of China 12074394 and 22576126Suzhou Industrial Park Health Talent Support Program YQWS202516Suzhou Science and Technology Research and Development Plan (Medical and Health Innovation) Project SYWD2025076the Open Project of the State Key Laboratory of Radiation Medicine and Protection GZK1202508
6 · The paper itself

Abstract

Radiation-induced intestinal injury (RIII) significantly limits the efficacy of abdominal and pelvic radiotherapy while also impairing patient quality of life. This condition is primarily driven by excessive reactive oxygen species (ROS) and dysregulation of Caspase-dependent apoptosis. Quercetin (QUE), a natural antioxidant flavonoid, exhibits radioprotective potential; however, the key signaling pathways it employs to regulate radiation-induced apoptosis remain to be elucidated. In vitro studies, IEC-6 cells (1-10 µg/mL QUE pretreatment followed by 0-8 Gy X-ray exposure) were conducted to analyze proliferation, clonogenic survival, ROS levels, apoptosis, and expression of RIII-related proteins and genes. Network pharmacology identified 47 overlapping targets associated with QUE and RIII, with AKT1 and CASP3 identified as hub targets, and the PI3K-AKT pathway recognized as a key regulatory pathway. A Caspase-3/7 inhibitor (HY-103346, H10) and AutoDock-Vina docking analysis were used to explore the involvement of Caspase-3-related apoptotic signaling. In vivo experiments using Drosophila melanogaster (W

Indexed as

Caspase 3IntestinesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuercetinRadiation Injuries, ExperimentalRadiation-Protective AgentsAnimalsApoptosisCell LineDrosophila melanogasterRatsSignal TransductionAkt1 protein, ratCasp3 protein, ratCaspase 3Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuercetinRadiation-Protective AgentsCaspase-3PI3K-AKT signaling pathwayQuercetinRadiation-induced intestinal injury (RIII)Radioprotection

Identifiers

PMID42525372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.