Evidence map›Paper›PMID 42525315›Full record

ReviewNano convergence2026

Programmable nanomedicine via bioorthogonal molecular engineering.

Sunwoo Im, Seyoung Koo, Jong Seung Kim

Abstract readReview
In one paragraph

Review in Nano convergence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sunwoo ImDepartment of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Korea.
Seyoung KooDepartment of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Korea. sykoo@hanyang.ac.kr.
Jong Seung KimDepartment of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.

Funding

National Research Foundation of Korea 2018R1A3B1052702National Research Foundation of Korea 2022R1C1C2007637National Research Foundation of Korea RS-2025-16652968
6 · The paper itself

Abstract

Bioorthogonal chemistry provides a versatile strategy for programming nanomedicines beyond static carrier design. It enables post-synthetic installation of functional modules on nanoparticle surfaces, spatiotemporal control of payload activation and release, and higher-order functions arising from nanoparticle aggregation or nanoparticle-cell conjugation in diseased tissues. These capabilities allow nanomedicines to be activated more selectively in space and time and to generate functions that are difficult to achieve with conventional formulations. This review summarizes recent advances in multiscale bioorthogonal engineering for programmable nanomedicines, focusing on surface functionalization, molecular control of drug release, and interparticle or cell-associated assembly, and discusses challenges and future directions.

Indexed as

Bioorthogonal chemistryDiagnostic imagingIn situ assemblyNanomedicinePost-functionalizationProdrug activationTargeted therapy

Identifiers

PMID42525315
PMCPMC13421674

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.