Evidence map›Paper›PMID 42525311›Full record

ReviewCurrent HIV/AIDS reports2026

Accelerating Low-Barrier Use of Long-Acting Antiretroviral Therapy to Maximize Impact in People with HIV and Viremia or Adherence Challenges.

Lauren F Collins, Casey Chmura, Morgan M Philbin, Jonathan A Colasanti

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lauren F CollinsDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Casey ChmuraDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Morgan M PhilbinDivision of Health and Society, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Jonathan A ColasantiDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. jonathan.colasanti@emory.edu.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
An EYE toward healthy aging in HIV: building evidence for multimorbidity screening and preventionK23AG084415 · NIA · EMORY UNIVERSITY · PI COLLINS, LAUREN FRANCES · 2023 to 2025
$535k
Center for AIDS Research, Emory University P30AI050409NIAID NIH HHS P30 AI050409NIA NIH HHS K23 AG084415NIA NIH HHS K23AG084415
6 · The paper itself

Abstract

purpose of reviewLong-acting (LA) antiretroviral therapy (ART) is rapidly revolutionizing the landscape of HIV treatment. Clinical trials for injectable cabotegravir/rilpivirine (CAB/RPV) only included certain populations, limiting FDA approval to a subset of people with HIV; frontline medical staff and community members (inclusive of PWH) employed resourcefulness, collaboration, and advocacy to maximize access. However, significant implementation hurdles have constrained uptake, and research about clinical outcomes in PWH who initiate LA-ART with viremia or adherence challenges is nascent. RECENT

findingsPWH who initiate LAI-ART with viremia, including those with adherence challenges, achieve and maintain viral suppression (VS) at rates similar to PWH who initiate with VS. LAI-ART, in combination with appropriate support and programming, can increase access to ART in PWH with viremia and/or adherence challenges. The overall cost, in terms of dollars and person-time, makes implementation challenging. Additional funding mechanisms are needed, alongside innovative research regarding effective programs and care delivery models, to maximize implementation.

Indexed as

Anti-HIV AgentsHIV InfectionsMedication AdherenceViremiaAdherence InterventionsHumansAnti-HIV AgentsCabotegravir/rilpivirineImplementation scienceLenacapavirLong-acting antiretroviral therapyPeople with HIVSex and gender differences

Identifiers

PMID42525311
PMCPMC13421287

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.