Live Birth Following Microdissection Testicular Sperm Extraction and Intracytoplasmic Sperm Injection: A Case Study of a Patient with Non-Obstructive Azoospermia and a Y-chromosome Microdeletion (Ym9; P3, Including AZFb, c Region).

Kei-Ichiro Uemura, Akira Nakashima, Hiro Furusaka-Kishimoto, Kyoko Kido, Kiyoaki Nishihara, Kosuke Ueda, Makoto Nakiri, Tsukasa Igawa

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Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Kei-Ichiro UemuraDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan. uemura_keiichirou@kurume-u.ac.jp.ORCID http://orcid.org/0000-0002-8239-6066

Akira NakashimaSora No Mori KYUSYU, Reproductive Clinic, Tenjinmachi1-6, Kurume, Fukuoka, Japan.

Hiro Furusaka-KishimotoDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan.

Kyoko KidoSora No Mori KYUSYU, Reproductive Clinic, Tenjinmachi1-6, Kurume, Fukuoka, Japan.

Kiyoaki NishiharaDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan.

Kosuke UedaDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan.

Makoto NakiriDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan.

Tsukasa IgawaDepartment of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume, Fukuoka, Japan.

Funding

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6 · The paper itself

Abstract

The azoospermia factor (AZF) region on the long arm of the Y chromosome is instrumental in spermatogenesis. In particular, complete deletion of the AZFa, AZFb, and AZFb + c regions is not an indication for microdissection testicular sperm extraction (MD-TESE) as there is no chance of sperm retrieval. This report presents a rare case of a successful live birth, following intracytoplasmic sperm injection (ICSI) using sperm from a patient with a microdeletion of the Y chromosome, including part of the AZFb, c region, who underwent MD-TESE. A 3X-year-old Japanese man with azoospermia was admitted to our hospital in October X. Scrotal ultrasonography, physical examination, and genetic examination resulted in a diagnosis of non-obstructive azoospermia with Y chromosomal microdeletion of Ym-9 P3 (deletion of sequence-tagged site markers [sY2990][sY1197][sy1191], including part of the AZFb region). Thus, ICSI resulted in a successful fertilization and the subsequent birth of a child, suggesting its potential application in the field of in vitro fertilization.

Indexed as

AzoospermiaChromosomes, Human, YLive BirthSex Chromosome Disorders of Sex DevelopmentSperm Injections, IntracytoplasmicSperm RetrievalAdultChromosome DeletionFemaleHumansInfertility, MaleMaleMicrodissectionPregnancySex Chromosome AberrationsTestisAZFbAzoospermiaMicrodissection testicular sperm extractionSpermY chromosomal microdeletion

Identifiers

PMID42525229

DOI10.1038/aja.2012.55

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