Evidence map›Paper›PMID 42525224›Full record

ArticleJournal of neurovirology2026

Diagnostic challenges in HIV-associated Burkitt lymphoma initially presenting with multifocal neurological symptoms.

Motohiro Okumura, Kenichi Sakuta, Yui Shiozawa, Yuichiro Muraoka, Yuri Mizuno-Shojima, Shota Nakagawa, Ai Iwauchi, Hideki Uryu, Yasuyuki Iguchi

Abstract readCase Reports
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In one paragraph

Article in Journal of neurovirology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Motohiro OkumuraDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. kuromaru.mate@gmail.com.ORCID https://orcid.org/0000-0003-1973-4816
Kenichi SakutaDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yui ShiozawaDivision of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Yuichiro MuraokaDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yuri Mizuno-ShojimaDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Shota NakagawaDivision of Infectious Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Ai IwauchiDepartment of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Hideki UryuDivision of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 46-year-old male initially presented with multifocal neurological symptoms including leptomeningeal involvement, multiple cranial nerve palsies, myeloradiculopathy, myelopathy, and cauda equina syndrome. On admission, the patient tested positive for the human immunodeficiency virus (HIV). Based on the initial physical examination, which suggested Guillain-Barré syndrome, plasma exchange was initiated; however, clinical improvement was limited. Further evaluation, including histopathological analysis of the ileocecal mass and flow cytometry of the cerebrospinal fluid, revealed Burkitt lymphoma with widespread involvement of the central and peripheral nervous systems. Despite the early initiation of chemotherapy, the patient died. This case illustrates the diagnostic complexity of neurological presentations in patients with HIV infection and suggests that Burkitt lymphoma may be included in the differential diagnosis of rapidly progressive multifocal neurological symptoms.

Indexed as

Burkitt LymphomaHIV InfectionsDiagnosis, DifferentialFatal OutcomeHumansMaleMiddle AgedBurkitt lymphomaCentral nervous systemHuman immunodeficiency virusMultifocal neurological symptomsPeripheral nervous system

Identifiers

PMID42525224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.