Evidence map›Paper›PMID 42525218›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Integrated Single-Cell and TCR Profiling Reveals Protection-Associated CD8

Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Can KongState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0009-3790-0161
Siang ChenState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0001-7281-5837
Maolin LiState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-4147-139X
Meng WangState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0001-5963-2462
Hailin ZhangState Key Laboratory of Veterinary Public Health and Safety, Beijing, China.
Bolun ZhouState Key Laboratory of Veterinary Public Health and Safety, Beijing, China.
Zhenhua XieJinyu Biotechnology Co. Ltd., Hohhot, China.
Chen WangJinyu Biotechnology Co. Ltd., Hohhot, China.
Peng GaoState Key Laboratory of Veterinary Public Health and Safety, Beijing, China.
Jianjun LuoState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-5550-9889
Hanchun YangState Key Laboratory of Veterinary Public Health and Safety, Beijing, China.ORCID https://orcid.org/0000-0003-3359-3925
Runsheng ChenState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Dongdong ZhangState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0004-5131-4824
Jie LiJinyu Biotechnology Co. Ltd., Hohhot, China.ORCID https://orcid.org/0009-0000-5695-7141
Jun HanState Key Laboratory of Veterinary Public Health and Safety, Beijing, China.ORCID https://orcid.org/0000-0002-7104-7223

Funding

Beijing Natural Science Foundation Haidian Origination and Innovation Joint Fund L222007China Postdoctoral Science Foundation 2024M763464National Natural Science Foundation of China 32025035National Natural Science Foundation of China 32330106Postdoctoral Fellowship Program of CPSF GZC20232902Sci-Tech Breakthrough Project of Inner Mongolia Autonomous Region 2025KJTW0015
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to global swine industry, yet the immune mechanisms underlying protective vaccination are incompletely understood. Here, we applied integrated single-cell RNA sequencing and T cell receptor (TCR) profiling to characterize immune responses in a PRRSV vaccination-challenge model spanning complete, partial, and non-protection outcomes. We identified distinct CD8

Indexed as

CD8+ T cell responsemodified live vaccine (MLV)porcine reproductive and respiratory syndrome virus (PRRSV)protective immunitysingle‐cell RNA sequencing (scRNA‐seq)

Identifiers

PMID42525218
PMCPMC13418511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.