ArticleJournal of computational neuroscience2026
Histamine regulation in shaping spindle refractoriness: a computational modeling study.
Article in Journal of computational neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The spindle refractory period refers to the interval following a spindle during which another spindle does not occur. Lengthening of the spindle refractory period (SRPL) is commonly observed in EEG recordings of patients with neuropsychiatric disorders (NPDs) and may contribute to cognitive impairments. Histamine (HA), a key neuromodulator of thalamic oscillations, has been implicated in spindle refractoriness. However, the pathways through which HA influences SRPL remain poorly understood. To address this issue, we extended the thalamic modeling framework to construct an HA-based thalamic neural mass model (HA-TNMM) incorporating HA-related neurophysiological mechanisms within a circuit composed of thalamocortical relay population (TCR) and thalamic reticular nucleus (TRN). In particular, we propose a mathematical expression to characterize the effects of HA on two critical currents: the calcium-activated K
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