Evidence map›Paper›PMID 42525164›Full record

ArticleLangenbeck's archives of surgery2026

Handgrip strength and diameter-product-derived psoas area estimate in end-stage liver cirrhosis: an exploratory single-center analysis.

Eugen Malamutmann, Christina Neuhaus, Lale Umutlu, Sophia T Schmitz, Miroslav Jalc, Christian G Klein, Jan Bednarsch, Ulf Neumann, Arzu Oezcelik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eugen MalamutmannDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany. eugen.malamutmann@uk-essen.de.ORCID http://orcid.org/0000-0003-4624-5890
Christina NeuhausDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Lale UmutluInstitute of Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Sophia T SchmitzDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Miroslav JalcDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Christian G KleinDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Jan BednarschDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Ulf NeumannDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.
Arzu OezcelikDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medicine Essen, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45147, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies suggest that handgrip strength may correlate with muscle mass in cirrhosis, but validation across diverse transplant cohorts remains limited. We sought to validate whether previously reported correlations between handgrip strength and computed tomography (CT)-derived psoas-area estimates hold in a single-center cohort of liver transplant candidates and to explore whether a bedside prediction model could be derived.

methodsIn this retrospective cohort study, 96 patients with end-stage liver cirrhosis undergoing transplant evaluation at University Hospital Essen (January 2020-December 2024) underwent standardized handgrip strength, 4-meter gait time, and diameter-product-derived psoas area estimates. Pearson correlation, multiple linear regression, and Cox proportional hazards analyses were performed with Benjamini-Hochberg correction for multiple comparisons.

resultsHandgrip strength significantly correlated with total psoas area ([Formula: see text], 95% CI 0.16-0.51, [Formula: see text]). Multiple linear regression yielded a prediction model ([Formula: see text]) achieving 72% sensitivity and 68% specificity for sarcopenia detection (AUC = 0.74). In multivariate Cox regression, each 100 mm

conclusionHandgrip strength shows a modest, statistically significant association with diameter-product-derived psoas area estimates in liver transplant candidates. The derived prediction model has limited accuracy ([Formula: see text], AUC = 0.74) and cannot defer clinically indicated CT imaging; it may assist in identifying candidates who warrant confirmatory imaging or closer nutritional follow-up.

Indexed as

End Stage Liver DiseaseHand StrengthLiver CirrhosisPsoas MusclesSarcopeniaAgedFemaleHumansLiver TransplantationMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedFrailtyHandgrip strengthLiver cirrhosisLiver transplantationMELD scorePsoas muscleSarcopenia

Identifiers

PMID42525164
PMCPMC13421185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.