Evidence map›Paper›PMID 42524884›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Innovative Test Strip-Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves.

Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuping SaSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Hui YuanSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Jingui MaSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Zhigang YangSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Mei WangSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Weibiao WangSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.ORCID https://orcid.org/0000-0003-0049-0604
Lingling YangSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Fen MaSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Weiman ZhangSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.
Gidion Wilson Mening'ooSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.ORCID https://orcid.org/0000-0002-5231-8884
Guoning ChenSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.ORCID https://orcid.org/0009-0005-6258-8000
Xueqin MaSchool of Pharmacy, Ningxia Medical University, Yinchuan, China.ORCID https://orcid.org/0000-0003-4818-5967

Funding

Key Research and Invention Program of Ningxia 2023BEG02014Key Research Projects of Ningxia Medical University XJKF240324,XJKF240330National Natural Science Foundation of China 82360684Natural Science Foundation of Ningxia 2024AAC02043Natural Science Foundation of Ningxia 2026AAC030216
6 · The paper itself

Abstract

Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi-target treatments. This study developed an innovative and efficient screening platform combining hydrogen peroxide test strip-based colorimetric sensing with affinity chromatography for rapid identification of acetylcholinesterase (AChE) inhibitors from complex herbal medicines. Applying this strategy, from Lycium barbarum leaves, we identified three potent inhibitors: chlorogenic acid, N-acetyl-N'-caffeoylputrescine (NANCP), and N-caffeoylputrescine (NCP), with IC

Indexed as

acetylcholinesteraseaffinity chromatographyalzheimer's diseasecolorimetric sensinglycium barbarum leavesn‐caffeoylputrescine

Identifiers

PMID42524884
PMCPMC13418505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.