Evidence map›Paper›PMID 42524848›Full record

ArticleCNS neuroscience & therapeutics2026

Decreased Control and Enhanced Reactivity: Dual Dysregulation Pattern of Cross-Frequency Coupling in Emotional Susceptibility of Non-Clinical Insomnia.

Siyu Li, Qingwei Chen, Wenxin Liu, Lingling Zhang, Zhiguo Jiang, Taotao Ru, Guofu Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siyu LiGuangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, China.ORCID 0000-0002-2454-3013
Qingwei ChenGuangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, China.ORCID 0000-0002-5458-0210
Wenxin LiuSchool of Psychology, South China Normal University, Guangzhou, China.ORCID 0000-0001-9785-0324
Lingling ZhangSchool of Psychology, South China Normal University, Guangzhou, China.ORCID 0009-0006-8330-9784
Zhiguo JiangProvincial Key Laboratory of Multimodal Perceiving and Intelligent Systems, College of Information Science and Engineering, Jiaxing University, Jiaxing, China.ORCID 0000-0002-1764-0827
Taotao RuGuangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, China.ORCID 0000-0002-6097-4160
Guofu ZhouGuangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, China.ORCID 0000-0003-1101-1947

Funding

China Postdoctoral Science Foundation 2025M773445Guangdong Provincial Key Laboratory of Optical Information Materials and Technology 2023B1212060065Guangdong Provincial Philosophy and Social Sciences Planning GD26YXL06Ministry of Education Research Project of Humanities and Social Sciences 24YJCZH239The Open Project of the Provincial Key Laboratory of Multi-modal Perception and Intelligent Systems MPIS202410Young Teacher Research Cultivation Fund of South China Normal University 24KJ27
6 · The paper itself

Abstract

objectiveInsomnia involves impaired emotional attention, yet the underlying neurophysiological mechanisms remain unclear. This study investigated neurobehavioral characteristics of emotional processing in insomnia, specifically examining modulations by emotional valence and intensity.

methodsTwenty-five individuals with non-clinical insomnia disorder (NCID) and 22 normal controls (NC) performed a two-choice oddball task with emotional images (varying in valence and intensity) during task-state EEG recording. Phase-amplitude coupling (PAC) and time-frequency analyses were utilized to assess neural dynamics.

resultsThe NCID group responded averagely slower and showed distinct negative bias, with response being faster to negative versus positive affective images. PAC analysis confirmed a dual dysregulation: the NCID group showed significantly reduced delta-beta coupling in frontal regions and significantly increased theta-beta coupling in occipital regions. Importantly, these coupling alterations were intensity-dependent; the NCID group showed a blunted dynamic range across intensities and lower frontal coupling specifically for high-intensity negative stimuli. Time-frequency analysis further revealed increased posterior theta power in the NCID group, while beta oscillations showed enhanced responses to negative stimuli in both groups.

conclusionInsomnia is characterized by altered emotional susceptibility involving intensity-dependent alterations in cross-frequency coupling (CFC). These findings clarify the neurophysiological mechanisms of emotional dysfunction in insomnia and highlight CFC as a potential biomarker for emotional regulation impairments.

Indexed as

BrainBrain WavesEmotionsSleep Initiation and Maintenance DisordersAdultElectroencephalographyFemaleHumansMalePhotic StimulationYoung Adultcross‐frequency couplingemotional susceptibilityinsomnia disordernegative biasphase‐amplitude coupling

Identifiers

PMID42524848
PMCPMC13418374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.