Evidence map›Paper›PMID 42524783›Full record

ArticleJACC. Case reports2026

Managing Aortic Regurgitation and Dynamic Aortic Thrombus in a Patient With Left Ventricular Assist Device.

Anna Stegmann, Anika Nagel, Pia Lanmüller, Gaik Nersesian, Daniel Lewin, Christoph Falkensteiner, Stephan Dreysse, Axel Unbehaun, Christoph Starck, Evgenij V Potapov

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna StegmannDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany. Electronic address: anna.stegmann@dhzc-charite.de.
Anika NagelDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Pia LanmüllerDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany.
Gaik NersesianDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Daniel LewinDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany.
Christoph FalkensteinerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Cardioanesthesiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany; Deutsches Herzzentrum der Charité, Institute for Artificial Intelligence in Medicine, Berlin, Germany.
Stephan DreysseCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Cardiology, Deutsches Herzzentrum der Charité, Berlin, Germany.
Axel UnbehaunDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany.
Christoph StarckDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Evgenij V PotapovDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with end-stage heart failure undergoing durable left ventricular assist device (dLVAD) implantation are at risk of developing de novo or progressive aortic regurgitation (AR) during long-term support. CASE SUMMARY: We report a dLVAD patient with significant AR, in whom transcatheter aortic valve replacement was unsuitable because of an enlarged aortic annulus and aortic thrombus. A complex hybrid approach included open thrombus removal from the ascending aorta under short circulatory arrest, temporary interventional occlusion of a not-accessible dLVAD outflow-graft, and surgical aortic valve replacement (SAVR). DISCUSSION: Aortic thrombus in dLVAD patients carries the risk of coronary, cerebral or peripheral embolism. In addition to this contraindication, SAVR was favored over transcatheter aortic valve replacement because of an aortic annulus diameter >28 mm, according to the institutional treatment algorithm. TAKE-HOME MESSAGE: In a dLVAD patient with AR and aortic thrombus, an individualized hybrid strategy enabled effective outflow-graft occlusion facilitating safe thrombus evacuation and SAVR.

Indexed as

aortic valvechronic heart failureleft ventricular assist devicethrombusvalve replacement

Identifiers

PMID42524783
PMCPMC13554896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.