Topsy-Turvy Heart: Multimodality Prenatal and Postnatal Imaging for Clinical Management.

Dominik Meyer, Julia Geiger, Roland Weber, Anke Meinhold, Elias Seidl, Emanuela Regina Valsangiacomo Buechel

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dominik MeyerDivision of Pediatric Cardiology, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Julia GeigerChildren's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Roland WeberDivision of Pediatric Cardiology, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Anke MeinholdChildren's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Intensive Care and Neonatology, University Children's Hospital Zurich, Zurich, Switzerland.

Elias SeidlChildren's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland; Division of Respiratory Medicine, University Children's Hospital Zurich, Zurich, Switzerland.

Emanuela Regina Valsangiacomo BuechelDivision of Pediatric Cardiology, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address: Emanuela.valsangiacomo@kispi.uzh.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTopsy-turvy heart is an extremely rare congenital heart disease characterized by an axial rotation of the heart owing to a strict supero-inferior orientation of the ventricles and to an elongation of the airways and neck vessels. CASE SUMMARY: We report a case diagnosed prenatally with topsy-turvy heart and aortopulmonary window, with high suspicion of associated airway abnormalities, using combined fetal echocardiography and fetal cardiac magnetic resonance. Immediately after birth, the newborn developed severe respiratory failure requiring mechanical ventilation. DISCUSSION: Multimodality imaging provided comprehensive assessment of the complex intracardiac anatomy and the severe associated vascular and airway anomalies, including severe bronchomalacia and parenchymal lung disease. Despite maximal intensive care support, the clinical condition of the newborn deteriorated rapidly. Considering the clinical course and all imaging findings, the interdisciplinary experts team, based on the available literature, estimated the prognosis as dismal and recommended redirection of care. TAKE HOME MESSAGE: Multimodality imaging used pre- and postnatally in newborns with complex heart disease helps for timely clinical decision making.

Indexed as

cardiac magnetic resonancecomputed tomographycongenital heart defectechocardiographyimaging

Identifiers

PMID42524781

DOI10.1016/j.jaccas.2026.109534

PMCPMC13571350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.