ArticleCureus2026
Sequential Logic-Gated Prioritization of microRNA Networks Identifies DKK1 as a Candidate Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease-Hepatocellular Carcinoma (MASLD-HCC) and Metastasis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is projected to become the leading cause of hepatocellular carcinoma (HCC) worldwide. Unlike fibrosis in other organs, liver fibrosis carries a higher risk of malignant transformation, suggesting that hepatic microenvironmental signaling promotes oncogenesis and metastasis. Our overarching hypothesis is that MASLD-HCC and metastasis are associated with reduced expression of tumor-suppressive microRNAs and increased expression of oncogenes. We undertook an in silico, logic-gated, prioritization strategy integrating MASLD-HCC-associated microRNA networks, HCC biomarker-associated microRNA networks, tumor suppressor scoring, and expression analyses to identify candidates associated with MASLD-HCC and metastasis. Sequential Boolean AND logic gating identified hsa-miR-101-3p, -206, and -613, each with tumor-suppressive activity and reduced expression in HCC and other cancers. All three microRNAs converged on a single node, Dickkopf-related protein 1(
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