ArticleCureus2026
Acute Diverticulitis as an Atypical Presentation of Alpha-Gal Syndrome.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha-gal syndrome (AGS) is an immunoglobulin E (IgE) mediated hypersensitivity reaction caused by tick bites. The body's immune response to tick bites can lead to the production of anti-alpha-gal IgE antibodies, disrupting the normal oral tolerance to food allergens. AGS typically results in delayed anaphylaxis after consuming red meat or certain medications and immediate anaphylaxis following tick bites; however, isolated gastrointestinal manifestations are increasingly being reported. We present a case of a 38-year-old female patient with a history of AGS who developed acute sigmoid diverticulitis with associated pelvic abscess, likely related to her AGS. Despite initiation of broad-spectrum intravenous antibiotics, the patient experienced persistent severe abdominal pain requiring diagnostic laparoscopy; however, bowel resection was ultimately avoided. The patient improved with continued intravenous antibiotics and had complete symptom resolution on follow-up. This case highlights the expanding gastrointestinal spectrum of AGS and raises the concern of an association between AGS-related immune dysregulation and inflammatory colonic pathology such as diverticulitis. Recognition of atypical gastrointestinal presentations of AGS is essential to reduce delays in diagnosis and misclassification as other gastrointestinal disorders.
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