ArticleJournal of cellular and molecular immunology2025
Aging shapes baseline immunity in sterile-housed female hAPOE mouse genotypes.
Article in Journal of cellular and molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Apolipoprotein E ε4 allele (APOE4) is a major risk factor in the development of late-onset Alzheimer's Disease (LOAD; AD) and has been associated with altered immunological responses, particularly under inflammatory challenge. Whether APOE genotype shapes baseline peripheral immunity across aging remains unclear. Because experimental context can influence immune phenotypes, we focus here on baseline profiles under specific-pathogen-free barrier housing (sterile housing) and discuss their implications. To this end, we highlight the peripheral immune profile in female humanized APOE mice (APOE3/3, APOE3/4, APOE4/4) maintained under sterile housing at 6, 9, and 15 months of age. Immunophenotyping of blood and spleen revealed significant age-related changes in B and T cell subpopulations and cytokine levels. Significant increases in activated and effector CD4
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