ArticleInfectious diseases & immunity2026
Characteristics, management, and outcomes of early symptomatic congenital syphilis in infants at a tertiary specialist hospital in Beijing from 2008 to 2024.
Article in Infectious diseases & immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The neonate and infant periods are critical time windows for diagnosing and treating congenital syphilis (CS) so as to prevent its adverse outcomes. In order to assist pediatricians in achieving early diagnoses and to standardize evaluations and treatments of early CS, this retrospective study described the clinical characteristics, management, and outcomes of infants with early symptomatic CS in Beijing, China, and compared the characteristics of neonatal syphilis with those of post-neonatal syphilis, aiming to enhance the prognosis for affected children. Methods: Clinical data, including demographics, clinical manifestations, laboratory test results, imaging reports, treatments, and follow-up outcomes, were collected from the electronic medical record system of Beijing Ditan Hospital, Capital Medical University (a tertiary-level general teaching hospital specializing in infectious diseases). The data pertained to patients admitted to the hospital from January 1, 2008, to December 31, 2024, who were diagnosed with early CS and met the inclusion criteria of this study. Nonparametric tests were used to compare the neonatal and post-neonatal groups for non-normally distributed continuous data, and Results: A total of 121 infants with early symptomatic CS were included in this study. Typical skin lesions ( Conclusion: Infants diagnosed with CS after the neonatal period exhibited more frequent and complex symptoms, a higher incidence of leukocytosis, and a greater likelihood of complications, underscoring the importance of early diagnosis.
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