Post-Infectious Purpura Fulminans in a Healthy Child: A Case Report.

Introduction: Purpura fulminans (PF) is a rare and life-threatening thrombohemorrhagic disorder characterized by rapidly progressive purpuric skin lesions caused by dermal microvascular thrombosis and disseminated intravascular coagulation (DIC). Post-infectious PF is an uncommon variant in children and is typically associated with transient acquired deficiencies of natural anticoagulant proteins. We present a case of severe postinfectious PF that highlights the extensive cutaneous necrosis seen in this type of PF despite the absence of systemic shock. Case Presentation: A previously healthy 3-year-old girl presented with rapidly progressive painful violaceous plaques on both shins. She was afebrile and hemodynamically stable. Laboratory studies revealed DIC and severe acquired Protein S deficiency with anti-Protein S antibodies. Diagnosis of PF was made. Microbiological testing was positive for Conclusion: Post-infectious PF should be suspected in children presenting with rapidly progressive purpuric lesions following recent infection. Early recognition and aggressive multidisciplinary management are essential to prevent life-threatening complications and limit permanent tissue damage.