Adenosine signaling promotes double-negative T-cell anticancer responses in conditions of CD8 T-cell lymphopenia.

Zhi Huang, Brionna King, Laura Naldi, Lucio Miele, Giulia Monticone

Abstract read

In one paragraph

Article in Blood immunology & cellular therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhi HuangDepartment of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA.ORCID 0000-0001-5043-9757

Brionna KingDepartment of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA.ORCID 0009-0007-9624-1560

Laura NaldiDepartment of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA.ORCID 0009-0006-1172-2748

Lucio MieleDepartment of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA.ORCID 0000-0002-5853-7287

Giulia MonticoneDepartment of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA.ORCID 0000-0003-1018-1274

Funding

Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI Arunava Roy · 2017 to 2026

$22.4M

NIGMS NIH HHS P20 GM121288

6 · The paper itself

Abstract

CD8 T-cell lymphopenia is observed in a variety of conditions, and has been linked with poorer survival, and increased risk of developing cancer and infections. An increase in double-negative T cells (DNTs), a subset of T cells that lack CD8 and CD4 coreceptors, has been reported in both human patients with CD8 T-cell lymphopenia and mice depleted of CD8 T cells. Promoting the generation of immunoprotective DNTs could compensate for the lack of CD8 T cells in affected patients, but strategies to generate protective DNTs remain unclear. In this study, we found that it is possible to promote immunoprotective antitumor DNTs under conditions of CD8 T-cell lymphopenia using the antileukemic drug forodesine. This work could have significant therapeutic implications for patients with CD8 T-cell lymphopenia, including patients with cancer.

Identifiers

PMID42524509

DOI10.1016/j.bict.2026.100031

PMCPMC13411137

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.