Evidence map›Paper›PMID 42524368›Full record

ArticleSensors & diagnostics2026

DISCO-LAMP: a novel discontinuous LAMP assay for isothermal antigen detection.

Benjamin M Thomas, Rudo A Simeon, Katherine L Yan, Vikas Chonira, Wesly T Chen, Emma L Webb, Caitlyn Mutchler, Alexi M Fernandez, Jinu Han, Zhilei Chen

Abstract read
In one paragraph

Article in Sensors & diagnostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin M ThomasGenetics and Genomics Interdisciplinary Program, Texas A&M University College Station Texas 77843 USA zchen4@tamu.edu.
Rudo A SimeonDepartment of Microbial Pathogenesis and Immunology, Texas A&M School of Medicine College Station Texas 77807 USA.
Katherine L YanDepartment of Microbial Pathogenesis and Immunology, Texas A&M School of Medicine College Station Texas 77807 USA.
Vikas ChoniraDepartment of Microbial Pathogenesis and Immunology, Texas A&M School of Medicine College Station Texas 77807 USA.
Wesly T ChenDepartment of Biochemistry and Biophysics, Texas A&M University College Station Texas 77843 USA.
Emma L WebbDepartment of Biochemistry and Biophysics, Texas A&M University College Station Texas 77843 USA.
Caitlyn MutchlerDepartment of Biochemistry and Biophysics, Texas A&M University College Station Texas 77843 USA.
Alexi M FernandezDepartment of Biochemistry and Biophysics, Texas A&M University College Station Texas 77843 USA.
Jinu HanDepartment of Microbial Pathogenesis and Immunology, Texas A&M School of Medicine College Station Texas 77807 USA.
Zhilei ChenGenetics and Genomics Interdisciplinary Program, Texas A&M University College Station Texas 77843 USA zchen4@tamu.edu.ORCID https://orcid.org/0000-0002-0244-3556

Funding

Artificial Ecology Sink as prophylaxis against viral infectionDP2AI136600 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHEN, ZHILEI · 2017 to 2017
$2.2M
A Novel Technology for Engineering Binders to Membrane ProteinsR21GM138811 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHEN, ZHILEI · 2020 to 2021
$416k
NIAID NIH HHS DP2 AI136600NIGMS NIH HHS R21 GM138811
6 · The paper itself

Abstract

Proximity ligation assay (PLA) is a highly sensitive protein detection method in which DNA probes conjugated to affinity reagents are brought into proximity upon binding the same target molecule, thereby enabling greatly accelerated ligation of the DNA strands. The detection of the ligated DNA typically relies on PCR, which requires temperature cycling. In this study, we report on a novel discontinuous (DISCO)-LAMP assay that enables the wash-free detection of PLA products

Identifiers

PMID42524368
PMCPMC13411199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.