ArticleSmart molecules : open access2026
Design, synthesis and activity evaluation of tetrahydroisoquinoline-based programmed cell death ligand 1 inhibitors.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song and 6 more
Abstract read
In one paragraphArticle in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
Menglin YuState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Sen CaiState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Yanyan PanDepartment of Central Laboratory Dalian Municipal Central Hospital Dalian Liaoning China.
Heshuang WangDepartment of Central Laboratory Dalian Municipal Central Hospital Dalian Liaoning China.
Fengwu ZhangState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Aiyu MaState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Shixuan LvState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.ORCID https://orcid.org/0009-0004-5853-9049 Xiuhan GuoState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.ORCID https://orcid.org/0000-0001-5989-5775 Shisheng WangState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Qiling SongState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Chunyan MaState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Shuai WangState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.
Li ZhangDepartment of Central Laboratory Dalian Municipal Central Hospital Dalian Liaoning China.
Jian WangViwit Pharmaceuticals Co., Ltd Zaozhuang Shandong China.
Qingwei MengState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.ORCID https://orcid.org/0000-0002-1743-2518 Yueqing LiState Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology Dalian Liaoning China.ORCID https://orcid.org/0000-0002-2976-9337 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Small molecule blockade of the programmed death receptor 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway represents a promising approach for tumor immunotherapy. Based on the previously developed 3D-quantitative structure-activity relationship pharmacophore model for PD-L1 inhibitors, virtual screening followed by homogeneous time-resolved fluorescence (HTRF) activity testing identified the compound {1-[(biphenyl-4-yl)methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-yl}acetic acid methyl ester (Compound
Indexed as
docking calculationsHTRFPD‐L1 inhibitorspharmacophore modelingSPRtetrahydroisoquinoline
Identifiers
PMID42524321
PMCPMC13410806
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