ArticleFrontiers in adolescent medicine2026
Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.
Article in Frontiers in adolescent medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Adolescence is a period notable for increased risk-taking behaviors, including substance use (SU). Longitudinal work has linked behavioral disinhibition, particularly impulsive dispositions and externalizing tendencies with SU, but the underlying neurobiological manifestations remain less well-defined. This study examined whether individual differences in reward-related striatal activity and impulsivity predicted mental health (externalizing symptoms) and SU outcomes (cannabis, nicotine, alcohol) over a year later. Methods: Adolescents ( Results: Behaviorally, gain cues elicited faster target-related RTs and higher HRs (vs. loss or neutral trials), and performance scaled with incentive magnitude. Gain (vs. neutral) cues elicited greater bilateral caudate activity where Conclusions: These findings suggest blunted striatal activity may reflect reduced motivational drive for lower-intensity rewards (e.g., fictitious MID monetary gains), which contribute to SU vulnerability via heightened behavioral disinhibition in pursuit of higher-intensity stimulation. Intervention strategies that upregulate everyday reward value and strengthen self-regulation may offer utility in reducing teen SU.
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