ArticleCase reports in gastrointestinal medicine2026
Analysis of Diagnosis and Treatment of Active Lupus Enteritis Accompanied by Intestinal Pseudo-Obstruction as the Initial Manifestation: A Case Report and Literature Review.
Article in Case reports in gastrointestinal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Analysis of Diagnosis and Treatment of Active Lupus Enteritis Accompanied by Intestinal Pseudo-Obstruction as the Initial Manifestation: A Case Report and Literature Review.Case reports in gastrointestinal medicine · 2026Article
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7 authors.
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Abstract
Background: Intestinal pseudo-obstruction (IPO) is a rare initial manifestation of systemic lupus erythematosus (SLE), often misdiagnosed as mechanical obstruction or malignant tumor, leading to unnecessary intervention measures and poor prognosis. Case Report: We report a 46-year-old female patient presenting with recurrent abdominal pain and IPO, ultimately diagnosed with SLE through multidisciplinary assessment. The patient exhibited positive antinuclear antibodies (ANAs) (+↑), homogeneous karyotype (+++ 1:1000↑), low complementemia, and lupus nephritis, meeting the diagnostic criteria for SLE. Abdominal CT showed small intestine and colon wall edema with characteristic "target sign" and mesenteric vascular congestion ("comb-like sign"). Initial treatment included pulse therapy with methylprednisolone (240 mg/day) combined with cyclophosphamide and hydroxychloroquine, with symptom relief, but recurrence occurred multiple times during the tapering period. Literature Review: Analysis of 54 cases of SLE-related IPO (1997-2025) indicated:demographic characteristics: 92.6% were female, and the median age at diagnosis was 31 years. Clinical features: 81.3% of patients presented with abdominal pain; 93.0% involved the small intestine. Imaging examinations: intestinal wall edema ("target sign") and mesenteric vascular hyperplasia ("comb-like sign"); these signs indicate SLE-related small bowel involvement. Immunological examinations: the positive rate of ANAs (ANA) was 75.9%, the positive rate of anti-double-stranded DNA antibody (anti-dsDNA) was 61.1%, and the positive rate of anti-SSA antibody was 42.5%. Prognosis: Despite immunosuppressive treatment, the recurrence rate was 25%; the mortality rate was 7.5%. Conclusion: For patients with recurrent IPO accompanied by low albuminemia, elevated D-dimer, and positive autoantibodies, autoimmune etiology must be considered. Early identification and immunosuppressive treatment are crucial to avoiding unnecessary surgery.
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