Evidence map›Paper›PMID 42524207›Full record

ArticleJournal of Cancer2026

Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis.

Xiaozheng Ou, Jinghong Xu, Yuting Jin, Yanqing Wang, Rongmin Yu, Jianhua Zhu, Weijuan Huang, Liyan Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaozheng OuBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, China.
Jinghong XuDepartment of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Yuting JinDepartment of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Yanqing WangDepartment of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Rongmin YuBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, China.
Jianhua ZhuBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, China.
Weijuan HuangBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, China.
Liyan SongBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Drug resistance in colorectal cancer (CRC) necessitates novel therapeutic strategies. This study investigated whether arteannuin B, a sesquiterpene lactone from Methods: Anti-CRC effects were assessed Results: Arteannuin B showed significant anti-colorectal cancer activity both Conclusion: Arteannuin B triggers ferroptosis-like cell death in CRC cells and suppresses xenograft growth, in association with inhibition of the mevalonate pathway. GDF15 contributes to arteannuin B-mediated suppression of HMGCS1 and GPX4 and to ferroptosis sensitivity.

Indexed as

Arteannuin BColorectal cancerFerroptosisGrowth differentiation factor 15.Mevalonate pathway

Identifiers

PMID42524207
PMCPMC13410655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.