Evidence map›Paper›PMID 42524120›Full record

ArticleEye banking and corneal transplantation2026

Agentic Artificial Intelligence in Eye Banking: A Proposed Workflow.

Ranit Karmakar, Elizabeth Kassahun Kiros, Siddharth Nath, Pearse A Keane, Krishna Kumar, John Lohmeier, Shameema Sikder, Eric Meinecke, Chris Hanna, Allen O Eghrari

Abstract read
In one paragraph

Article in Eye banking and corneal transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ranit KarmakarImage Analysis Collaboratory, Harvard Medical School, Boston, Massachusetts, USA.
Elizabeth Kassahun KirosDana Center for Preventive Ophthalmology, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Siddharth NathDana Center for Preventive Ophthalmology, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Pearse A KeaneUniversity College London, Institute of Ophthalmology.
Krishna KumarRocky Mountain Lions Eye Bank, Aurora, Colorado, USA.
John LohmeierRocky Mountain Lions Eye Bank, Aurora, Colorado, USA.
Shameema SikderDana Center for Preventive Ophthalmology, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.
Eric MeineckeGeorgia Eye Bank, Atlanta, Georgia, USA.
Chris HannaUtah Lions Eye Bank, Murray, Utah, USA.
Allen O EghrariDana Center for Preventive Ophthalmology, Wilmer Eye Institute at Johns Hopkins, Baltimore, Maryland, USA.

Funding

NEI NIH HHS L30 EY024746
6 · The paper itself

Abstract

Purpose: To develop an agentic artificial intelligence (AI) framework that streamlines and standardizes eye bank operations by automating donor screening, image analysis, and tissue suitability assessment under expert supervision. Methods: A modular, on-premises, multi-agent system was designed consisting of three AI agents. The Donor Screening Agent analyzes medical histories to identify contraindications for ocular donation. The Corneal Image Analysis Agent interprets multimodal images, including specular microscopy, slit-lamp, and optical coherence tomography, to quantify endothelial cell density, morphology, and clarity. The Suitability Assessment Agent integrates outputs from both preceding agents to generate structured recommendations for transplantation, research use, or rejection. Each agent operates locally to ensure privacy, real-time processing, and compliance with health information regulations. Results: The proposed architecture replaces fragmented manual workflows with a unified, intelligent system that reduces variability, accelerates evaluations, and enhances transparency. By enabling consistent and rapid analysis of donor data and corneal images, the system can improve tissue utilization and decrease discard rates. A modular, low-latency design supports deployment in diverse settings, including low- and middle-income countries, where connectivity and infrastructure may be limited. Conclusions: Agentic AI offers a scalable pathway toward a standardized eye banking process by combining automation with human oversight. This approach has the potential to improve decision quality, operational efficiency, and equity in corneal transplantation. It carries implications for both limited resource settings and the broader context of transplantation medicine.

Indexed as

AIartificial intelligenceeye bankingspecular microscopy

Identifiers

PMID42524120
PMCPMC13409418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.