Evidence map›Paper›PMID 42524106›Full record

ArticleJournal of the Endocrine Society2026

Unraveling the natural history of lipodystrophy syndromes: insights from the prospective LD-Lync study.

Merve Celik Guler, Maria Cristina Foss-Freitas, Ilgin Yildirim Simsir, Matheos Yosef, Michelle Ashmus, Shokoufeh Khalatbari, Donatella Gilio, Demircan Guler, Diarratou Kaba, Anabela Dill Gomes and 25 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03087253 (Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and Their Complications), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03087253 recruitingnot on this map

Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and Their Complications

Typeobservational_patient_registrySponsorUniversity of MichiganRan2018 to 2034Enrolled500ConditionsLipodystrophy (Genetic or Acquired, Non HIV)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Merve Celik GulerDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-1112-7640
Maria Cristina Foss-FreitasDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0002-1350-1125
Ilgin Yildirim SimsirDivision of Endocrinology and Metabolism, Department of Internal Medicine, Ege University Faculty of Medicine, Izmir 35100, Turkey.ORCID https://orcid.org/0000-0002-6801-8499
Matheos YosefDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-3284-6580
Michelle AshmusDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Shokoufeh KhalatbariDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Donatella GilioDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0001-9609-6286
Demircan GulerDepartment of Internal Medicine, Health Sciences University Izmir Tepecik Education and Research Hospital, Izmir 35020, Turkey.ORCID https://orcid.org/0000-0002-3639-4625
Diarratou KabaDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Anabela Dill GomesDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Trinity NealDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Becca TuskaDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Maiah BrushDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Andra StrattonLipodystrophy United, Los Lunas, NM 87031, USA.
Rasimcan MeralDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-4026-5049
Ozge BesciDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-3135-9617
Michael HwangDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Britney TraceyDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Drake Stanton RosenbergDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0009-0009-9164-1092
Chika Divine UwanduDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Marinna OkawaDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Brianna BriteDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Marissa LightbourneDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-5498-0452
Yingying LuoDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Deanna JonesDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Kaneesha WallaceDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Cathie SpinoDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Natalia Prado BorisDepartment of Clinical Medicine, and Clinical Research Unit, Hospital Complex of the Federal University of Ceará/EBSERH, Fortaleza, CE 60430, Brazil.ORCID https://orcid.org/0000-0003-3006-3574
Abdelwahab Jalal EldinDepartment of Internal Medicine, Wilson Medical Center, Wilson, NC 27893, USA.
Cynthia M ValerioBrazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0003-2292-1735
Virginia Oliveira FernandesDepartment of Clinical Medicine, and Clinical Research Unit, Hospital Complex of the Federal University of Ceará/EBSERH, Fortaleza, CE 60430, Brazil.ORCID https://orcid.org/0000-0002-4311-6551
Renan Magalhães Montenegro JuniorDepartment of Clinical Medicine, and Clinical Research Unit, Hospital Complex of the Federal University of Ceará/EBSERH, Fortaleza, CE 60430, Brazil.ORCID https://orcid.org/0000-0001-7287-8726
Baris AkinciIzmir Biomedicine and Genome Center, Izmir 35340, Turkey.ORCID https://orcid.org/0000-0002-8634-4845
Rebecca J BrownDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-2589-7382
Elif A OralDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0002-9171-1144

Funding

Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
NCATS NIH HHS UM1 TR004404
6 · The paper itself

Abstract

Context: Lipodystrophy syndromes represent a diverse group of rare disorders characterized by deficiency and abnormal distribution of adipose tissue that may be generalized (GL) or partial (PL), leading to significant metabolic abnormalities. Objective: To elucidate the natural history of critical comorbidities of lipodystrophy. Methods: Ongoing, prospective, multicenter, registry study (LD Lync; NCT03087253). This analysis reports 266 patients with lipodystrophy enrolled until October 11, 2023. Results: The median age was 39 years ([28-54], range: 6-76 years; male/female: 50/216). Hypertriglyceridemia ( Conclusion: Our findings confirm that patients with lipodystrophy face a significant risk of comorbidities, with an earlier onset of diabetes, hypertriglyceridemia, and hepatic steatosis in those with GL compared to PL. This registry will serve as a crucial resource for gaining insights into the burden of disease in lipodystrophy.

Indexed as

diabeteshypertriglyceridemiainsulin resistanceleptinlipodystrophypancreatitis

Identifiers

PMID42524106
PMCPMC13409154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.