ArticleAdvanced pharmaceutical bulletin2026
Optimizing Expression of a Llama-Based Anti-PSMA Nanobody in
Article in Advanced pharmaceutical bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Purpose: Nanobodies possess unique properties that make them promising as tumor targeting agents. Prostate-specific membrane antigen (PSMA), overexpressed in prostate cancer, can be an excellent target for prostate cancer diagnosis. This study aimed to express and purify an anti-PSMA nanobody (PSMA-Nb) and assess its potential for detecting PSMA antigen in prostate cancer through immunohistochemistry (IHC). Methods: The PSMA-Nb gene was subcloned into pET-28a and expressed in Results: PSMA-Nb (~27 kDa) was enriched in Conclusion: The superior features of nanobodies support antibody-based diagnostics in solid tumors. Purified PSMA-Nb detected PSMA on cancer cells and FFPE tissues, indicating a promising tool for prostate cancer diagnosis.
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