Evidence map›Paper›PMID 42524040›Full record

ArticleFrontiers in immunology2026

Human seminal plasma suppresses neutrophil antimicrobial functions and promotes bacterial survival.

Gabriel Mayoral-Andrade, Gabriela Vásquez-Martínez, Israel Cotzomi-Ortega, Gamaliel Sánchez-Orellana, Jeimy M Lopez-Torres, Diana Zepeda-Orozco, Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Abraham Salvador Majluf-Cruz, María Del Socorro Pina-Canseco and 10 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gabriel Mayoral-Andrade *The Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Gabriela Vásquez-Martínez *The Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Israel Cotzomi-Ortega *The Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Gamaliel Sánchez-OrellanaThe Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Jeimy M Lopez-TorresThe Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Diana Zepeda-OrozcoThe Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.
Laura Pérez-Campos MayoralCenter for Research Faculty of Medicine UNAM-UABJO, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
María Teresa Hernández-HuertaSECIHTI, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
Abraham Salvador Majluf-CruzRegional General Hospital 1 "Dr. Carlos MacGregor Sánchez Navarro", Medical Research Unit in Thrombosis, Hemostasis, and Atherogenesis, Mexico City, Mexico.
María Del Socorro Pina-CansecoCenter for Research Faculty of Medicine UNAM-UABJO, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
Margarito Martínez-CruzBiochemistry and Molecular Biology, National Technological of Mexico/IT Oaxaca, Oaxaca, Mexico.
Gabriel Mayoral-CansecoBiochemistry and Molecular Biology, National Technological of Mexico/IT Oaxaca, Oaxaca, Mexico.
Carlos Alejandro Vásquez-MartínezCenter for Research Faculty of Medicine UNAM-UABJO, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
Víctor Cruz HernándezHospital General Dr. Aurelio Valdivieso, IMSS-Bienestar, Oaxaca, Mexico.
Luz María Moreno PomboHospital General Dr. Aurelio Valdivieso, IMSS-Bienestar, Oaxaca, Mexico.
Adriana Carriedo BlancoBiochemistry and Molecular Biology, National Technological of Mexico/IT Oaxaca, Oaxaca, Mexico.
Eduardo Pérez-Campos MayoralCenter for Research Faculty of Medicine UNAM-UABJO, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
Héctor Martínez-RuizCenter for Research Faculty of Medicine UNAM-UABJO, Faculty of Medicine and Surgery, Autonomous University Benito Juárez of Oaxaca, Oaxaca, Mexico.
Eduardo Pérez-CamposBiochemistry and Molecular Biology, National Technological of Mexico/IT Oaxaca, Oaxaca, Mexico.
Juan de Dios Ruiz-RosadoThe Kidney and Urinary Tract Research Center, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.

Funding

Contrasting roles for neutrophils and macrophages during acute pyelonephritisK01DK128379 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RUIZ ROSADO, JUAN DE DIOS · 2021 to 2025
$719k
NIDDK NIH HHS K01 DK128379
6 · The paper itself

Abstract

Human seminal plasma (HSP) plays an important role in shaping the reproductive immune environment, but its effects on modulating neutrophil antimicrobial functions and pathogen clearance remain unclear. In this study, we investigated the immunomodulatory effects of HSP on key neutrophil effector responses, including reactive oxygen species (ROS) production, neutrophil extracellular trap (NET) formation, phagocytosis, and bacterial killing. Human neutrophils were stimulated with calcium ionophore A23187, phorbol 12-myristate 13-acetate (PMA), or uropathogenic

Indexed as

Microbial ViabilityNeutrophilsSemenUropathogenic Escherichia coliAnimalsExtracellular TrapsHumansMaleMiceMice, KnockoutNADPH Oxidase 2PhagocytosisReactive Oxygen SpeciesNADPH Oxidase 2Reactive Oxygen Speciesbacterial clearancehuman seminal plasmaNETosisneutrophilsphagocytosisprostaglandinsreactive oxygen speciesuropathogenic E. coli (UPEC)

Identifiers

PMID42524040
PMCPMC13407980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.