ReviewJournal of dental research, dental clinics, dental prospects2026
Unraveling The Link Between Stress and the Severity of Apical Periodontitis: A Systematic Review of Animal Studies.
Review in Journal of dental research, dental clinics, dental prospects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Apical periodontitis can occur due to the host immune response, with the release of antibodies, cytokines, and chemokines by stress as a systemic risk factor. This systematic review aimed to investigate the relationship between stress and the severity of apical periodontitis. Methods: A detailed search strategy was conducted on the "PubMed (MEDLINE), Web of Science (all databases), Scopus, ScienceDirect, EMBASE, and Cochrane Library" databases. Data were screened based on the eligibility criteria. Articles assessing the severity of apical periodontitis using different parameters in stress-induced animals in comparison with stress-free animals were selected. The risk of bias assessment was conducted using SYRCLE's RoB tool. The GRADEpro tool was used to determine the overall quality of evidence. Results: Four articles were selected after a full-text assessment. Animals under stress exhibited increased levels of inflammatory cells. The extension of the bone loss and the periapical lesion size differed according to the measurement and visualization methods. All the included articles had a high risk of bias. GRADEpro revealed that the overall certainty of evidence for the included studies was very low. Conclusion: Under the limitations of this systematic review, an increasing effect of stress on the inflammatory infiltrate was reported in apical periodontitis. Future well-conducted animal studies are warranted to further elaborate on the effects of stress parameters on the severity of apical periodontitis with convenient experimental conditions and advanced evaluation methods.
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