ArticleFrontiers in cell and developmental biology2026
The maternal KRAB-ZFP ZFPOBI1 reveals structural constraints governing ERV transcriptional co-option in mouse oocytes.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transposable elements (TEs) constitute a major fraction of mammalian genomes and play key roles in gene regulation, particularly during early development. Endogenous retroviruses (ERVs) are highly active in oocytes and early embryos, where their long terminal repeats (LTRs) can act as alternative promoters to generate LTR-initiated transcripts (LITs). Krüppel-associated box zinc finger proteins (KRAB-ZFPs) on the other hand repress TE activity in a sequence-specific manner through recruitment of the co-repressor TRIM28. Here, we identify the mouse KRAB-ZFP ZFPOBI1 as a previously uncharacterized, maternally expressed KRAB-ZFP that selectively targets the RLTR10 LTR subfamilies of the ERVK class. ZFPOBI1 binding is associated with robust TRIM28 recruitment and more modest changes in H3K9me3 enrichment at RLTR10 elements in mouse embryonic stem cells, consistent with canonical KRAB-ZFP-function. In oocytes, we show that RLTR10 elements contribute to LIT formation in a structure-dependent manner. While LTRs serve as transcriptional start sites, efficient splicing into downstream exons predominantly occurs via internal (-int) ERV sequences, indicating a functional separation of transcription initiation and RNA processing. Maternal deletion of
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