Evidence map›Paper›PMID 42523908›Full record

ArticleFrontiers in global women's health2026

Establishing trimester-specific reference intervals of vitamin K-dependent protein C, protein S, and antithrombin and exploring the impacts of abnormal anticoagulation tests on adverse perinatal complications or outcomes.

Lei Li, Zhengwen Xu, Jiazi Zeng, Hongyuan Zhu, Lin Liu, Yifei Chen, Jingnan Zhang, Huihui Yan, Jingyi Niu, Yue Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in global women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei Li *Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Zhengwen Xu *Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Jiazi ZengDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Hongyuan ZhuDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Lin LiuDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Yifei ChenDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Jingnan ZhangDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Huihui YanDepartment of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Jingyi NiuDepartment of Ophthalmology, Beijing Xuanwu Traditional Chinese Medicine Hospital, Beijing, China.
Yue ZhangInformation Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Shaofei SuCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Yanhong ZhaiDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Zheng CaoDepartment of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Owing to complex physiological changes that take place in the anticoagulation system during pregnancy, reference intervals (RIs) based on non-pregnant women are not optimal for clinical diagnosis and treatment. In this cohort study, we aimed to establish trimester-specific RIs of vitamin K-dependent protein C (PC), protein S (PS), and antithrombin (AT) in singleton pregnancies and assess the risks of developing adverse pregnancy outcomes. Methods: Using the nonparametric approach, the first- ( Results: The trimester-specific RIs for the PS and AT showed decreasing trends over the entire pregnancy ( Conclusion: With the established trimester-specific RIs of vitamin K-dependent PC, PS, and AT, our study sheds light on the potential application of these tests in identifying women with increased risks of developing various pregnancy complications and adverse postpartum outcomes.

Indexed as

adverse outcomeantithrombinpregnancyprotein Cprotein Sreference interval

Identifiers

PMID42523908
PMCPMC13407839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.