Observational studyFrontiers in public health2026
A post-marketing surveillance study of a human rabies vaccine in China (2020-2024).
Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: To evaluate the safety profile of Yisheng Jun'an® freeze-dried human rabies vaccine (Vero cell) through post-marketing surveillance in China (2020-2024), focusing on adverse reaction patterns and influencing factors. Methods: A retrospective observational study analyzed 2,419 adverse events from the national Direct Adverse Event Reporting System (DAERS) and manufacturer-collected data. Adverse reactions were categorized by type, severity, and subgroup (age, gender, dose number, etc.) using the Medical Dictionary for Regulatory Activities (MedDRA) for standardized coding. Analysis of incidence rates with 95% confidence intervals, use of the chi-square test to assess associations, and cross-subgroup comparisons were conducted to elucidate the safety profile of the vaccine. Results: In total, 2,419 AEs were reported, yielding an overall incidence of 7.406 per 100,000 doses (95% CI 7.11-7.71). Systemic reactions comprised 83.38% and local reactions 16.62%. Seventeen serious adverse events (0.70%) occurred; no deaths were reported and all recovered. The most common categories were general disorders/administration-site conditions (83.38%) and immune system disorders (5.70%). AEs were most frequent after the first dose (85.49%) and declined markedly with subsequent doses. Systemic reactions were more common in children (0-10 years: 37.99%). Conclusion: Yisheng Jun'an® rabies vaccine exhibits a favorable safety profile with mild-to-moderate reactions, supporting its use in post-exposure prophylaxis.
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