SynthesisFrontiers in dental medicine2026
Antimicrobial additives in resin-based endodontic sealers: a scoping review of antimicrobial efficacy, physicochemical properties, and cytotoxicity.
Synthesis in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Root canal sealers based on polymeric resins have incorporated nanostructured and antimicrobial ingredients to enhance antimicrobial activity and prevent root canal reinfection. This scoping review aimed to evaluate antimicrobial additives incorporated into resin-based endodontic sealers and their effects on antibacterial efficacy, physicochemical properties, and cytotoxicity. Methods: Electronic searches were conducted in Cochrane Library, PubMed, MEDLINE, Scopus, and Web of Science using text keywords related to resin-based endodontic sealers, antibacterial additives, physicochemical properties, and cytotoxic effects. From 1,473 records retrieved, 63 articles were eligible for full-text screening and 33 studies were included. Results: The included studies evaluated various antibacterial additives, including nanoparticles, chlorhexidine, quaternary ammonium compounds, herbal extracts, and several chemical agents incorporated into resin-based endodontic sealers. Many studies reported enhanced antibacterial activity against Enterococcus faecalis, with some demonstrating reduced biofilm formation and sustained antimicrobial effects over time. The physicochemical properties, including flow, solubility, and setting time, were generally maintained within acceptable limits. Cytotoxicity outcomes were either reduced or unchanged in most combinations, indicating favorable biocompatibility. Conclusion: In conclusion, incorporating antimicrobial additives into resin-based endodontic sealers may enhance antibacterial efficacy without significantly compromising physicochemical properties or cytocompatibility. However, further studies are required to confirm long-term biological performance and clinical effectiveness. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261388075, identifier CRD420261388075.
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