ArticleInternational journal of clinical pediatric dentistry2026
The Antimicrobial Efficacy of New Antibiotic Combinations against Bacteria Associated with Endo-perio Lesions in Deciduous Teeth: An
Article in International journal of clinical pediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endodontic infections in deciduous teeth disseminate rapidly into surrounding areas due to anatomical complexities enhancing the formation of endo-perio lesions. Inadequate treatment of such conditions usually leads to premature tooth loss, jeopardizing dental arch integrity. Objective: To investigate the efficacy of clindamycin (C), metronidazole (M), doxycycline (D), and their combination CMD against bacteria associated with endo-perio lesions in deciduous teeth for topical application. Materials and methods: The bacteria responsible for endo-perio lesions such as Results: The combination CMD was most effective, followed by clindamycin, doxycycline, and metronidazole, to eliminate test bacteria. The intergroup comparisons of all test groups and intragroup comparisons among the individual agents for MIC Conclusion: The combination CMD can effectively eliminate bacteria associated with endo-perio lesions in deciduous teeth to decrease therapeutic failures, promote endodontic lesion healing, and increase the survival of the teeth in the dental arch.
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