ArticleFrontiers in medicine2026
Correlation between CT-determined emphysema and the severity of acute exacerbation of chronic obstructive pulmonary disease: a cross-sectional study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The high prevalence of chronic obstructive pulmonary disease (COPD) poses a significant social burden. Emphysema is a basic pathological change associated with poor lung function in stable COPD. However, few studies have focused on the potential role of emphysema in acute exacerbation of COPD (AECOPD). The current study aimed to explore the correlation between CT-determined emphysema and other main physiological parameters of severe AECOPD. Methods: In total 90 hospitalized patients with AECOPD participated in this cross-sectional study. All of them underwent chest CT scans and lung function tests as planned. Emphysema was defined as the percentage of low attenuation areas (LAA) below -950 Hounsfield Units (%LAA Results: %LAA Conclusion: In patients with severe AECOPD, CT-determined emphysema is associated with decreased lung function and poor HRQoL. Trial registration: The study was registered on the Chinese Clinical Trial Registry (registration number: ChiCTR2000033101).
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