ArticleFrontiers in neurology
Relationship between hemoglobin glycation index and mild cognitive impairment risk in middle-aged and elderly people: a cohort study from CHARLS 2011-2018.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Blood glucose levels may be correlated with cognitive function. The hemoglobin glycation index (HGI) quantifies the difference between observed and predicted glycated hemoglobin (HbA1c) to characterize individual variation in hemoglobin glycation susceptibility. This analysis aimed to explore the association between HGI values and mild cognitive impairment (MCI) risk in middle-aged and elderly people. Methods: This cohort study included non-MCI participants (aged ≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS) database in 2011, with follow-up data collected through 2018. The association between HGI and MCI risk was investigated by Cox regression analyses, and the results were summarized as hazard ratio with 95% confidence interval [HR (95%CI)]. Further analyses were carried out according to different characteristic subgroups. The restricted cubic splines (RCS) curve was applied to examine the non-linear relationship. Results: A total of 5,723 participants were included in this analysis, of whom 1,088 (19.01%) had MCI and 4,635 (80.99%) did not. HGI exhibited a significant U-shaped relationship with the risk of MCI ( Conclusion: Low and high HGI values were related to a higher MCI risk among middle-aged and elderly people, and HGI values may assist in identifying high-risk populations for MCI.
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